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Synonym: 2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine
Molecular Formula: C10H15NO4
Molecular Weight: 213.23
CAS Number: 487-79-6
Purity: >99%, Glutamate, free;
Solubility: H2O soluble
Description:
Kainic acid is a natural marine product originally isolated from the
red marine alga D. Simplex. It is a potent central nervous system
stimulant, and has been developed as the prototype neuroexcitatory
amino acid for the induction of seizures in experimental animals, at a
typical dose of 10-30 mg/kg in mice.Kainic acid is neuroexcitotoxic and
epileptogenic, acting through specific kainate receptors.
References:
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Chtarto A, Bockstael O, Gebara E, Vermoesen K, Melas C, et al. (2013) An Adeno-Associated Virus-Based Intracellular Sensor of Pathological Nuclear Factor-?B Activation for Disease-Inducible Gene Transfer. PLoS ONE 8(1): e53156. doi:10.1371/journal.pone.0053156
- Kristen Ryan, Donald S. Backos, Philip Reigan, and Manisha Patel (2012) Post-Translational Oxidative Modification and Inactivation of Mitochondrial Complex I in Epileptogenesis. The Journal of Neuroscience, August 15, 2012, 32(33):11250-11258
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